Dickson Despommier notes in his article Vertical Farming that 

The advent of agriculture ushered in an unprecedented increase in the human population and their domesticated animals. Farming catalyzed the transformation of hunter-gatherers into urban dwellers. Today, over 800 million hectares is committed to agriculture, or about 38% of the total landmass of the Earth. Farming has re-arranged the landscape in favor of cultivated fields and herds of cattle, and has occurred at the expense of natural ecozones, reducing most of them to fragmented, semi-functional units, while completely eliminating others. Undeniably, a reliable food supply has allowed for a healthier life style for most of the civilized world, while the very act of farming has created new health hazards.

 Also, See . . .