It has been qualitatively understood for a long time that climate change will

have widely varying effects on human well-being in different regions of the world.

The spatial complexities underlying our relationship to climate and the geographical

disparities in human demographic change have, however, precluded the development

of global indices of the predicted regional impacts of climate change on

humans. Humans will be most negatively affected by climate change in regions

where populations are strongly dependent on climate and favourable climatic

conditions decline.Here we use the relationship between the distribution of human

population density and climate as a basis to develop the first